Potassium Channel

KcsA

Potassium Channel

Related Products

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (796)
Antibodies (6)
Related Compound Screening Libraries (1)

By Effects:	Controls (6) Inhibitors (504) Agonists (14) Antagonists (33) Activators (158) Modulators (25) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-110192

ML 297	Activator	99.14%
ML 297 (VU 0456810) is a potent and selective GIRK_1/2 activator, with an EC₅₀ of 0.16 μM. ML 297 is potential for the treatment of epilepsy.

HY-108596

BL-1249	Activator	99.81%
BL-1249 is a nonsteroidal anti-inflammatory agent (NSAID) and a potassium channel activator. BL-1249 potently activates K_2P2.1 (TREK-1) and K_2P10.1 (TREK-2) with EC₅₀ values of 5.5 μM and 8.0 μM, respectively. BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K_2P subfamilies. BL-1249 exhibits more selective for the bladder (EC₅₀ of 1.26 μM) than vascular tissue (EC₅₀ of 21.0 μM).

HY-100712

DPO-1	Inhibitor	98.39%
DPO-1 is a potent inhibitor of the voltage-gated potassium channel subtype K_v1.5 and a blocker of ultrarapid delayed rectifier potassium current. DPO-1 prevents atrial arrhythmia.

HY-158155

CVN293	Inhibitor	99.91%
CVN293 is a selective and brain permeable potassium ion (K⁺) channel KCNK13 inhibtor with IC₅₀s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia.

HY-B0267A

Oxybutynin chloride	Inhibitor	99.15%
Oxybutynin chloride is an oral active and competitive mAChR antagonist with K_is of 14.3 and 5.55 nM for specific [³H]NMS binding in the mouse bladder and cerebral cortex, respectively. Oxybutynin chloride inhibits vascular Kv channels in a manner independent of anticholinergic effect, with an IC₅₀ value of 11.51 μM. Oxybutynin chloride reduces muscle spasm in the bladder and urinary tract, can be used in study of overactive bladder syndrome (OAB). Oxybutynin (chloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0563A

Ropivacaine hydrochloride monohydrate	Inhibitor	99.82%
Ropivacaine hydrochloride monohydrate is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane. Ropivacaine is widely used for regional anesthesia and neuropathic pain management in vivo.

HY-16738A

Eleclazine hydrochloride	Inhibitor	99.66%
Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC₅₀ value of <1 μM and approximately 14.2 μM, respectively. Eleclazine hydrochloride shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine hydrochloride can be used to research cardiac arrhythmias.

HY-14187

Amiodarone	Inhibitor	98.32%
Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC₅₀ of 19.1 μM.

HY-120348

ML67-33	Activator	≥99.0%
ML67-33 is a selective activator of temperature- and mechano-sensitive K_2P channels. ML67-33 rapidly and reversibly affects K_2P2.1 (TREK-1) with EC₅₀s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively.

HY-14183

Vernakalant Hydrochloride	Inhibitor	99.33%
Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na⁺ and atria-preferred K⁺ channel blocker. IC₅₀ for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channel^wt, Kv1.5 channel^I508F, Kv1.5 channel^T479A, respectively.

HY-Y0078

Cinnamyl Alcohol	Activator	99.80%
Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity.

HY-14290A

Pinacidil monohydrate		99.85%
Pinacidil (P-1134) monohydrate, an antihypertensive agent, is a potassium channel activator.

HY-119322

Tifenazoxide	Activator	≥99.0%
Tifenazoxide (NN414) is a potent, orally active and SUR1/Kir6.2 selective K^ATP channels opener. Tifenazoxide has antidiabetic effect, can inhibit glucose stimulated insulin release in vitro and in vivo, and has a beneficial effect on glucose homeostasis.

HY-B0881

Acetohexamide	Inhibitor	99.67%
Acetohexamide is a first-generation sulfonylurea agent used in research related to type 2 diabetes; it stimulates the pancreas to secrete insulin.Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas.

HY-18719

Endoxifen (Z-isomer)	Inhibitor	99.20%
Endoxifen Z-isomer is an oral active Tamoxifen (HY-13757A) metabolite, inducing an anti-estrogenic effect in breast cancer cells expressing ERα. Endoxifen Z-isomer inhibits hERG. This effect is concentration-dependent, with an IC₅₀ value of 1.6 μM.

HY-101396

ICA-069673	Activator	99.20%
ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC₅₀s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells.

HY-P0191A

Charybdotoxin TFA	Inhibitor	98.84%
Charybdotoxin TFA, a 37-amino acid peptide, is a K⁺ channel blocker.

HY-104027

ML402	Activator	99.86%
ML402, a thiophene-carboxamide, is a selective K_2P2.1(TREK-1) and K_2P10.1(TREK-2) activator. ML402 is inactive against K_2P4.1(TRAAK).

HY-B2133

Cloperastine hydrochloride	Inhibitor	99.39%
Cloperastine hydrochloride inhibits the hERG K⁺ currents in a concentration-dependent manner with an IC₅₀ value of 27 nM.

HY-15707

NS6180	Inhibitor	99.80%
NS6180 is a new orally active KCa3.1 channel inhibitor. NS6180 inhibits cloned human KCa3.1 channels with an IC₅₀value of 9 nM. NS6180 can be used for the research of inflammatory bowel disease (IBD) .

Potassium Channel Compound Library

Compound library containing a variety of potassium channel inhibitors and activators.

269compounds HY-L119

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (796)

Antibodies (6)

Related Compound Screening Libraries (1)

Potassium Channel Related Products (796):